Study of Lipoprotein Profile in Myocardial Infarction

Abstract

Introduction:

It is well established that there are four major risk factors, i.e., hypercholestrolaemia, hypert ension, heavy cigarette smoking and diabetes mellitus which lead to the development of atheros clerosis. Among these the best documented one is the correlation between blood lipid levels and coronary heart disease.Our aim was to confirm the recently developed idea that HDL-c bears a negative correlation with the occurrence of coronary heart disease.

Materials and Methods:
The present study of lipoprotein profile was undertaken on 30 patients of myocardial infarct ion of both sexes between 35-85 years of ages. The cases selected were the once admitted to the coronary care unit Mayo Hospital Lahore. Control group included 18 age matched males and 5 females.

Results:

Statistical significance of results was assessed by student “t” test. Significantly high values of cholesterol, VLDL and chylomicrons (P.< .01), P < .001, P < .05) were obtained in group A as compared with group E. The difference in LDL between these two groups however, was not statistically significant.The difference in chylomicron values in these groups however were not statistically significant. dowever, i-IDL---c levels were lower, in patients than in normal controls.

Discussion:

The serum cholesterol and lipoprotein levels on the morning after myocardial infarction showe d a significant difference between the cases and control group. It is an established fact that hypercholestrolaemia is one of the major risk factor which leads to the development of atheros clerosis.In conclusion the present preliminary study indicates that there is inverse relationship between HDL Cholesterol and serum B lipoproteins and further HDL—Cholesterol has negative association with the risk of coronary heart disease.