The Pre-Excitation Syndrome: Epidemiological And Genetic Study

Abstract

Introduction:

Pre-excitation occurs because during organogenesis accessory pathways are formed of the conducting musculature in the heart, by which impulses are spread to the ventricles, by-passing the pathways of normal conduction of stimulus by the atrioventricular node, which most frequently results in attacks of paroxysmal tachycardia or tachyarrhythm ias’3. There are 60 different hypotheses to Explain.

Subjects and Methods:
This study is divided into two parts. In the first part data on clinical-epidemiological research on pre-excitation is analyzed. While in the second part antigens of the HLA system are analyzed in patients with various variants of pre-excitation.

Results:
Table 1. shows a finding of pre-excitatiOn according to sex in a general population of 4210 subjects in 1969. A short P-R interval vas found in 42 subjects (1.0%). This finding was somewhat more frequent in subjects aged 45 to 49 years. A finding of short P-R interval with widened QRS complex and delta wave was found in two subjects, i.e., 0.05%. One of those subjects had type A and other type B of pre-excitation.

Discussion:
According to this investigation, a short P-R interval in the ECG is present in 1.0% of the adult population, while a finding of short P-R interval, widened QRS and delta wave is present in 0.05% çSe;;tOI1 study. These two, however, are

Our two subjects with a short P-R interval, widened QRS complex and delta wave at the begin fling of the R wave, one subject did not report for a check—up after three years, while in one subject this finding appeared for the first time. Of these three subjects, type B pre-excitation was present in two and A type in one.