PATTERN OF CORONARY ATHEROSCLEROSIS IN SMOKERS AND NON-SMOKERS

Abstract

OBJECTIVE:
The study was carried out to determine the pattern of coronary atherosclerosis among smokers and nonsmokers.
METHODS:
The study was carried out in LNH; angiograms of smokers and non-smokers were reviewed and recorded on
Performa. Variables were displayed as percentages, compared by chi square test. R-R and CI were also
obtained fo different variables.
RESULTS:
A total of 400 patients were enrolled, 184 were smokers and 216 were non-smokers. There were 83% male
smokers and 73% males in non-smoking group. Hypertension was seen in 43%, DM was seen in 31% and
Dyslipidemia was seen in 28% of smokers. Among smokers 71% had lesions in LAD (p-0.002), 56% in Cx (p-
0.001) and 59% in RCA (p-0.013). 18% of smokers had single vessel disease, 26% had two-vessel disease and
42% had triple vessel disease (p-0.04). CABG was done in 37% and 24% were managed by PTCA. Among
non-smokers 53% had hypertension, 32% had DM and 33% found to have dyslipidemia. LAD was involved
in 59%, Cx in 37% and RCA was involed in 46% of non-smokers. Triple vessel disease was seen in only 29%
and CABG was performed in 26% of non-smokers.
CONCLUSION:
Smokers tend to have significantly high multi-vessel disease with lower incidence of known predisposing risk
factors for atherosolerosis. LAD was more commonly affected in smokers and more of our CAD patients who
smoke underwent CABG.