Resting Global Longitudinal Strain as a Noninvasive Diagnostic Tool in Predicting Significant Coronary Artery Disease in Patients with Non-ST-Elevation MI and Normal Left Ventricular Systolic Function on Echocardiography

Authors

  • Muhammad Sohail Saleemi Chaudhary Pervaiz Elahi Institute of Cardiology, Multan, Pakistan
  • Ammar Akhtar Chaudhary Pervaiz Elahi Institute of Cardiology, Multan, Pakistan
  • Muhammad Abdul Rahman Sikandar Chaudhary Pervaiz Elahi Institute of Cardiology, Multan, Pakistan
  • Muhammad Tauqeer Chaudhary Pervaiz Elahi Institute of Cardiology, Multan, Pakistan
  • Zubair Zaffar Chaudhary Pervaiz Elahi Institute of Cardiology, Multan, Pakistan
  • Tariq Abbas Chaudhary Pervaiz Elahi Institute of Cardiology, Multan, Pakistan

DOI:

https://doi.org/10.47144/phj.v57i2.2735

Abstract

Objectives: This study aimed to assess the relationship between resting global longitudinal strain (GLS) and significant coronary artery disease (CAD) in patients with Non-ST Elevation Myocardial Infarction (NSTEMI) and normal ejection fraction (EF).

Methodology: We enrolled 108 patients with NSTEMI and normal EF in this observational cross-sectional study. Resting GLS was measured, and coronary angiography was performed to assess CAD. The relationship between significant CAD and GLS was analyzed using the chi-square test. The specificity, sensitivity, positive predictive value, negative predictive value, and accuracy of GLS in predicting CAD were calculated.

Results: The mean age of the patients was 49.05 ± 7.28 years. The study had a male predominance. Diabetes was present in 30 patients (27.8%), hypertension in 31 patients (28.7%), dyslipidemia in 19 patients (17.6%), and 65 patients (60.2%) were smokers. Normal strain was observed in 36 patients (33.3%), while 72 patients (66.7%) had reduced strain. Significant CAD was present in 72 patients (66.7%). The p-value for the association between significant CAD and reduced GLS was <0.01. The sensitivity, specificity, and accuracy of GLS in predicting CAD were 91.7%, 83.3%, and 88.9%, respectively.

Conclusion: GLS can effectively predict the presence of significant CAD in patients with NSTEMI and normal left ventricular systolic function on echocardiography.

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Published

2024-06-18

How to Cite

1.
Saleemi MS, Akhtar A, Sikandar MAR, Tauqeer M, Zaffar Z, Abbas T. Resting Global Longitudinal Strain as a Noninvasive Diagnostic Tool in Predicting Significant Coronary Artery Disease in Patients with Non-ST-Elevation MI and Normal Left Ventricular Systolic Function on Echocardiography. Pak Heart J [Internet]. 2024Jun.18 [cited 2024Sep.19];57(2):95-9. Available from: https://pakheartjournal.com/index.php/pk/article/view/2735

Issue

Vol. 57 No. 2 (2024): Pakistan Heart Journal

Section

Original Article

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