TIMI RISK INDEX, A SIMPLE TOOL IN EMERGENCY PERCUTANEOUS REVASCULARIZATION FOR THE PREDICTION OF CONTRAST INDUCED NEPHROPATHY

Authors

  • Ali Bin Naseer National Institute of Cardiovascular Diseases, Karachi, Pakistan
  • Rajesh Kumar National Institute of Cardiovascular Diseases, Karachi, Pakistan
  • Jawaid Akbar Sial National Institute of Cardiovascular Diseases, Karachi, Pakistan
  • Musa Karim National Institute of Cardiovascular Diseases, Karachi, Pakistan

DOI:

https://doi.org/10.47144/phj.v55iSupplement1.2443

Abstract

Objectives: Contrast induced nephropathy (CIN) is a common complication seen after primary percutaneous coronary intervention (PCI) which can contribute to increased morbidity and mortality in patients of acute ST elevation myocardial infarction (STEMI). Aim of this study was to validate the TIMI Risk Index (TRI) for the risk stratification of CIN in patients undergone primary PCI.

Methodology: A total of 507 consecutive patients of STEMI undergone primary PCI at a tertiary care cardiac center were included for this study. Patients in Killip class IV at presentation, patients with history of any PCI and chronic kidney diseases were excluded from this study. TRI was calculated using the formula “heart rate  systolic blood pressure” and post-procedure serum creatinine level increase of either 25% or 0.5 mg/dL was taken as CIN.

Results: A total of 507 patients were included in this study out of which 82.2% were males and 17.8% were females. In total 8.7% (44) patients developed CIN. In the receiver operating characteristic (ROC) curve analysis, area under the curve (AUC) for TRI was found to be 0.717, [0.649 to 0.758] for the prediction of CIN. Sensitive, specificity, positive predictive value and negative predictive value of TRI>22.8 to predict the development of CIN were 59.09%, 76.69%, 19.55% and 95.19% respectively.

Conclusion: In conclusion, our study has consolidated the findings of previous studies using TIMI risk index in STEMI patients undergoing primary PCI and has established that this easy to calculate and readily accessible score has good accuracy to evaluate the risk of CIN in primary PCI setting and could be of great help to take any pre-emptive strategies in those identified at high risk of post-procedure CIN.

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Published

2022-11-17

How to Cite

1.
Naseer AB, Kumar R, Sial JA, Karim M. TIMI RISK INDEX, A SIMPLE TOOL IN EMERGENCY PERCUTANEOUS REVASCULARIZATION FOR THE PREDICTION OF CONTRAST INDUCED NEPHROPATHY. Pak Heart J [Internet]. 2022Nov.17 [cited 2024Mar.29];55(Supplement1):S27. Available from: https://pakheartjournal.com/index.php/pk/article/view/2443