LEFT VENTRICULAR DIASTOLIC FUNCTION ABNORMALITIES IN PATIENTS WITH NON-INSULIN DEPENDENT DIABETES MELLITUS

Abstract

Objectives: Left ventricular diastolic dysfunction (LVDD) is a prevalent condition among patients with non-insulin dependent diabetes mellitus (NIDDM). The aim of this study was to determine the frequency of the LVDD in patients with NIDDM at a tertiary care cardiac center of Karachi, Pakistan.

Methodology: This descriptive cross-sectional study included NIDDM patients without history of ischemic heart disease, on anti-hypertensive medication, diagnosed with valvular heart disease, congenital heart disease, arrhythmias, chronic respiratory illness, or with clinically overt heart failure (HF) or history of HF or concomitant systolic dysfunction. Transthoracic echocardiography was performed and LVDD was diagnosed.

Results: A total of 114 patients with NIDDM of less than five years were included in this study. Most of the patients were 41 to 60 years of age with mean age of the 52.23±10.85 years. Out of 114 cases, 58(50.9%) were male. Frequency of LVDD was observed to be 61.4% (70/114). With respect to age groups, rate of LVDD was high in above 60 years of age patients that is 90% (18/20) and it was observed 64.9% (24/37) in 51 to 60 years of age. Rate of LVDD was also high in male patients than female with frequency of 70.7% (41/58) vs. 51.8% (29/56).

Conclusion: A significant number of patients with NIDDM were found to have LVDD. Increased frequency of LVDD was observed to be associated with male gender and increased age of the patients.