SERUM RATIO ANALYSIS OF CRP/IL-6 IN PATIENTS OF PERIODONTITIS AND CARDIOVASCULAR DISEASES

Abstract

Objective: To explore the connection of periodontitis with cardiovasculardiseases through ratio analysis of CRP/IL-6 in patients with both pathologies.

Methodology: It was an cross-sectional study and involved participants of 30-70year of age. All the subjects were broadly classified into three classes, selectedby convenience sampling technique in to healthy controls, periodontitis patientsand cardiac patients having periodontitis. Their Serum levels for C-RP and IL-6was assessed through sandwich ELISA technique. One Way ANOVA as statisticaltool, was used to measure the significant difference amongst studied groups.

Results: About 95 participants were included with 56 males and 39 females.There were 21% healthy controls, 36% periodontitis and 41% cardiac patients.Females showed 1.7, 0.7 and 0.1 times raised serum ratio levels of CRP/IL-6 ascompared to males, in cardiac patients with mild periodontitis, cardiac patientswith severe periodontitis and mild periodontitis alone respectively. While incategory of severe periodontitis, males exhibited 0.33 times more C-RP/IL-6 ratioconcentrations in contrast to their counterpart females. Overall we found thatwith increase in periodontal and cardiac pathology, the ratio level of CRP/IL-6 isdecreased in both genders separately and altogether, with significantly provedstatistical difference (p<0.05).

Conclusion: In both genders, with increase in pathology, serum ratio levels of CRP/IL-6 are decreased, also females exhibited more C-RP/IL-6 values incomparison to males with only periodontitis and periodontitis in addition tocardiac pathology.

Key Words: Periodontitis, Cardiovascular Diseases, Ratio analysis, CRP, IL-6