IMPACT OF HYPERINSULINEMIA ON MORBIDITY AND MORTALITY FOLLOWING ACUTE MYOCARDIAL INFARCTION

Authors

  • Syed Farhat Abbas Shah
  • Mohammad Hafizullah
  • Taufiq A. Mufti
  • Abdul Hadi
  • Syed Tahir Shah

DOI:

https://doi.org/10.47144/phj.v44i3-4.14

Keywords:

Hyperinsulinemia, Acute myocardial infarction, In-hospital Morbidity and Mortality.

Abstract

Objective: To study the association of hyperinsulinemia, insulin resistance andits impact on morbidity and mortality following acute myocardial infarction(AMI).

Methodology: This prospective observational study was carried out atcardiology department, Lady Reading Hospital, Peshawar from May toDecember 2008. A total of 110 patients with first acute myocardial infarctionwere assessed for fasting insulin and grouped on the basis of normal or highinsulin level. The patients were given standard therapy and evaluated formorbidity and in hospital mortality.

Results: More patients in high insulin group were obese (72% vs. 23%,p=0.001), hypertensive (70% vs. 23%, p=0.001), diabetic (70% vs. 16%,p=0.001) and had higher evidence of heart failure i,e Killip class II & III(60% vs.34%, p=0.04) and Killip class IV(20% vs. 7%, p=0.17). These patients also hadhigher fasting glucose (158% ± 25 vs. 103 ± 18 mg/dl, p=0.02) andtriglyceride (245 ± 40 vs. 165 ± 35 mg/dl, p=0.01). More patients among nonsurvivors had high insulin (80% vs. 38%, p=0.002) in survivor group.

Conclusion: Hyperinsulinemia is positively associated with obesity, diabetes,hypertension and higher morbidity and mortaliy following acute myocardialinfarction.

Downloads

Download data is not yet available.

Author Biographies

Syed Farhat Abbas Shah

Department of Cardiology,Lady Reading Hospital, Peshawar -Pakistan and Assistant Professor

Mohammad Hafizullah

Department of Cardiology,Lady Reading Hospital, Peshawar -Pakistan and  Professor

Downloads

How to Cite

1.
Shah SFA, Hafizullah M, Mufti TA, Hadi A, Shah ST. IMPACT OF HYPERINSULINEMIA ON MORBIDITY AND MORTALITY FOLLOWING ACUTE MYOCARDIAL INFARCTION. Pak Heart J [Internet]. 2012Apr.25 [cited 2024Dec.24];44(3-4). Available from: https://pakheartjournal.com/index.php/pk/article/view/14

Issue

Vol. 44 No. 3-4 (2011): Pakistan Heart Journal

Section

Original Article

License

When an article is accepted for publication in the print format, the author will be required to transfer exclusive copyright to the PHJ and retain the rights to use and share their published article with others. However, re-submission of the full article or any part for publication by a third party would require prior permission of the PHJ.

Online publication will allow the author to retain the copyright and share the article under the agreement described in the licensing rights with creative commons, with appropriate attribution to PHJ. Creative Commons attribution license CC BY 4.0 is applied to articles published in PHJ https://creativecommons.org/licenses/by/4.0/