CORELATION OF BODY MASS INDEX WITH INDICES OF DIASTOLIC FUNCTION IN NORMOTENSIVE, NONDIABETIC PATIENTS

Abstract

Objective: To determine the association between body mass index and indices ofdiastolic function in normotensive and nondiabetics patients.

Methodology: This cross sectional study was carried out at department ofcardiology , Post Graduate Medical Institute Lady Reading Hospital Peshawar,from 1st March 2012 to 30th September 2012. Patients of either gender, agemore than 40 years, who presented to cardiology OPD with cardiac problemsother than heart failure symptoms were included. Patients BMI was calculated.Detailed echocardiographic study was done and EF, E' and E/E' ratio werecalculated. Correlation between BMI and diastolic function parameters wasassessed by multivariate logistic regression analysis and Pearson's correlationcoefficient.

Results: A total of 100 patients with mean age of 50.6 ± 4.62 years wereenrolled. Of them 42% were males. The study sample was grouped into threeaccording to their BMI: Group 1: patients of normal weight (BMI less than 25.0kg/m ). Group 2: overweight patients (BMI between 25- 29.9 kg/m ) and Group 3were obese (BMI more than 30 kg/m ). Using Tissue Doppler Imaging (TDI) fordiastolic function, E' was measured and E/É ratio was calculated. Mean E/E' ingroup 1 was 8.10±1.74, while E' was 7.67±0.97 cm/s. Mean E/E' in group 2was 8.84±1.69 and E' was 6.54±1.01 . E/E' in group 3 was 10.46± 2.53and E' was 6.23±1.16 . Patient with higher BMI had lower E' wave(R =0.22; p=0.001) and higher E/E' ratio (R 0.14;p=0.002). In separate subanalyses BMI had significant Correlation with lower E' ( 0.47, p <0.01) andhigher E/E' ( 0.38, p <0.001).

Conclusion: Higher BMI is a associated with worsening of diastolic functionregardless of traditional risk factors for diastolic dysfunction.

Key Words: BMI (Body Mass Index), Diastolic Dysfunction, E/E' Ratio, Obesity,Tissue Doppler Imaging, Early Diastolic Mitral Annular Velocity